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dimethylamino group considerably enhances the MOR affinity, as in U-47700. By contrast, embedding that same fundamental nitrogen into a cyclic pyrrolidine ring tremendously enhances the KOR affinity, as in U-50488. MOR/KOR selectivity is affected from the NU-47700 has become unlawful in all sorts, and also the DEA has positioned the substance into
[5] It experienced under no circumstances previously been claimed from the scientific or patent literature, and was initial determined by laboratories in Japan in March 2012 as an component in artificial cannabis smoking cigarettes blends, in addition to a linked compound APICA.[6] Structurally, it carefully resembles cannabinoid compounds from the
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